 |
|
 |
|
|
MOLECULAR & CELLULAR MECHANISMS OF CARCINOGENESIS & MUTAGENESIS
|
|||||
|
MMG 991 Special Topics In Microbiology
BMB 960 Special Topics In Biochemistry GEN 800 Genetics Seminar CMB 800 Cell & Molecular Biology Seminar |
|||||
|
Class 1 Jan 12 Introduction to DNA Repair, Mutagenesis and Recombination by Veronica M. Maher. Introduction to the Multi-Step Process of Carcinogenesis by J.
Class 2 Jan 19 DNA REPAIR: PREVENTING MUTAGENESIS Section 1) Nucleotide Excision Repair: Photoproducts, Bulky Adducts-XP patients
All Read
Section 2) Mismatch Repair;
Eric Marrotte presenting Class 3 Jan 26 ADDITIONAL TYPES OF REPAIR AND MUTAGENESIS Section 1) Transcription-coupled repair Neli Ragina Presenting All Read Mellon,Section 2) XP Variant patients and Role of Pol eta Samantha Taffner presenting All Read All Read W.G. McGregor, D. Wei, V.M. Maher, and J.J. McCormick. Abnormal, error-prone bypass of photoproducts by xeroderma pigmentosum variant cell extracts results in extreme strand bias for the kinds of mutations induced by ultraviolet light. Mol. Cell. Biol. 19, 147-154 (1999).Class 4 Feb 2 TRANSLESION SYNTHESIS BY ERROR-PRONE POLYMERASE ZETA & hRev1(hRev3/hRev7) adn the ROle of hRev1 All Read All Read
Section 1) Catalytic Subunit (hRev3) Tak Ko Presenting hRev7) McNally et al., Human homolog of S. cerevisiae Rev7, is involved in cell survival and the production of UV-induced mutations in human cells (2006). (Presenter Only) (Presenter Only) Section 2) hRev1 and its interaction with hRev3 and hRev7 Kannika Siripattarapravat presenting hRev1) Xi-De Wang,
THE MULTI-STEP PROCESS OF CARCINOGENESIS
Class 5 Feb 9 Chronic Myelogenous Leukemia Deininger, M., Buchdunger, E., Druker, B.J. The development of imatinib as a therapeutic agent for chronic myeloid leukemia. Blood. 105:2640-53, (2005).Tak Ko & Kannika Siripattarapravat presenting Class 6 Feb 16 Skin Cancer p53 Hussein, M.R. Ultraviolet radiation and skin cancer: molecular mechanisms. J Cutan Pathol. 32:191-205 (2005). Charis Chambers & Philip Ludwig presenting Class 7 Feb 23 Pancreatic Cancer Garcea, G., Neal. C.P., Pattenden, C.J., Steward, W..P, Berry, D.P. Molecular prognostic markers in pancreatic cancer: a systematic review. Eur J Cancer 41:2213-36 (2005).Samantha Taffner presenting/Justin McCormick presenting
Class 8 March 2 Cervical Cancer Mark Zimmerman Presenting/Justin McCormick presenting All Read Scheurer, M.E., Tortolero-Luna, G., Adler-Storthz, K. Human papillomavirus infection: biology, epidemiology, and prevention. Int J Gynecol Cancer. 15:727-46 (2005).Presenter Only Clifford, G.M., Rana, R.K., Franceschi, S., Smith, J.S., Gough, G., Pimenta, J.M. Human papillomavirus genotype distribution in low-grade cervical lesions: comparison by geographic region and with cervical cancer. Cancer Epidemiol Biomarkers Prev. 14:1157-64 (2005).Presenter Only Kim, H.G., Yamal, J.M., Xu, X.C., Hu, W., Boiko, I., Linares, A., Vlastos, A.T., Atkinson, E.N., Malpica, A., Hittelman, W.N., Follen, M. Cervical chromosome 9 polysomy: validation and use as a surrogate endpoint biomarker in a 4-HPR chemoprevention trial. Gynecol Oncol. 99(Suppl 1):S32-7 (2005).Presenter Only Nair, S., Pillai, M.R. Human papillomavirus and disease mechanisms: relevance to oral and cervical cancers. Oral Dis. 11:350-9 (2005).--------------Spring Break March 6-10----------------------- Class 9 March 16 Colon Cancer Eric Marrotte presenting All Read Grady, W.M. Genomic instability and colon cancer. Cancer and Metastasis Reviews 23: 11-27, 2004. Stem Cells & Cancer The class presenting Read any two of these papers to discuss “stem cells and cancer” as a group.
Class 10 March 23 1) Retinoblastoma All Read Mittnacht, S. The retinoblastoma protein-from bench to bedside. Eur. J Cell Biol. 84:97-107, 2005.2) Tumor Suppressor Cells KangAe Lee presenting Zhu, L. Tumour suppressor retinoblastoma protein Rb: A transcriptional regulator. Eur. J Cancer. 41: 2415-2427, 2005.All Read Payne, S. R., and Kemp, C.J. Tumor suppressor genetics. Carcinogenesis. 26 (12): 2031-2045, 2005.Rick Tobey presenting Tucker, T. and Friedman, J.M., Pathogenesis of hereditary tumors: beyond the “two-hit” hypothesis. Clin. Genet. 62: 345-357, 2002.Paige, A.J.W. Biomedicine and Diseases: Review: Redefining tumour suppressor genes: exceptions to the two-hit hypothesis. CMLS, Cell. Mol. Life Sci. 60: 2147-2163, 2003. Bignold, L. P. The cell-type-specificity of inherited predispositions to tumours: review and hypothesis. Cancer Letters. 216:127-146, 2004. Class 11 March 30 Breast Cancer All Read Johnston, S.R.D. and Dowsett, M. Aromatase Inhibitors for Breast Cancer: Lessons from the Laboratory. Nature Reviews – Cancer 3: 821-831, 2003.Neli Ragina & Charles Miller presenting
HOW CELLS DEAL WITH DNA DAMAGE THAT COULD LEAD TO A CELL BECOMING MALIGNANT
Class 12 April 13 DAMAGE AVOIDANCE All Read Z. Li, W. Xiao, J. J. McCormick and V. M. Maher. Identification of a protein essential for a major pathway used by human cells to avoid UV-induced DNA damage Proc. Natl. Acad. Sci., USA, 99 4459-4464, 2002.Section 1) Avoiding replication past fork-blocking damage Mark Zimmerman Presenting Section 2) Replication past cross-links and DNA Class 13 April 20 ROLE OF SUMOLYATION, UBIQUITINATION, AND PCNA All Read Helleday, T. Pathways for mitotic homologous recombination in mammalian cells. Mutat. Res. 532, 103-15, 2003.Freidberg, E.C., and Lehmann, A.R., and Fuchs, R. P.P. Trading places: how do DNA polymerases switch during translesion DNA synthesis? Mol. Cell 499-505, 2005. Section 1) Philip Ludwig presenting Lehmann, A.R. Replication of damaged DNA by translesion synthesis in human cells. 579, 873-6, 2005. Kannouche, P.L., Wing, J., and Lehmann, A.R. Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage. Mol. Cell, 14, 491-500, 2004.
Section 2) KangAe Lee presenting Nakanishi, K., Yang, Y.-G., Pierce, A.J., Taniguchi, T., Digweed, M., D’Andrea, A., Wang, Z.-Q., Jasin, M. Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair. Proc. Natl Acad SciNiedernhofer, L.J., Lalai, A.S., and Hoeijmakers, J.H. Fanconi anemia (cross) linked to DNA repair. Cell, 123, 1191-8, 2005. Class 14 April 27 NON-HOMOLOGOUS END-JOINING Section 1) Charles Miller presenting
Section 2) Charis Chambers presenting
|
|||||
Last Updated on 4/14/2006
|